ABCD2 Break Apart FISH Probe

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ABCD2BA-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ABCD2BA-20-AQOR 20 (40 μL) 200 μL color color Request Pricing

Gene Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : ABCD2

Gene Name : ATP binding cassette subfamily D member 2

Chromosome : CHR 12: 396,513,32-395,309,65

Locus : 12q12

Alt. Genes : HNRNPA3P1

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