This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CFHR1BA-20-REGO | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-REGR | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-GROR | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CFHR1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
Gene Symbol : CFHR1
Gene Name : Complement factor H related 1
Chromosome : CHR 1: 196,819,729-196,832,188
Locus : 1q31.3
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