This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ECH1BA-20-REGO | 20 (40 μL) | 200 μL |
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| ECH1BA-20-REGR | 20 (40 μL) | 200 μL |
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| ECH1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| ECH1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ECH1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ECH1BA-20-GROR | 20 (40 μL) | 200 μL |
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| ECH1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ECH1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
Gene Symbol : ECH1
Gene Name : Enoyl-CoA hydratase 1
Chromosome : CHR 19: 388,318,56-388,154,21
Locus : 19q13.2
Alt. Genes : CLEC3A
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