This region includes a endogenous retrovirus long-terminal repeat (LTR)-derived sequence that binds SRY (sex determining region Y)-box 2 (SOX2) and functions as an enhancer of the proline dehydrogenase (oxidase) 1 (PRODH) gene. This sequence acts synergistically with a CG-rich region downstream of the transcription start site to promote expression of PRODH. Cytosine methylation of the LTR element but not the CG-region can block enhancer activity. The orthologous sequence in chimpanzee does not function as an enhancer, suggesting that regulation by this region is human-specific. [provided by RefSeq, Oct 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERVPRODHBA-20-REGO | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-REGR | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-ORGR | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-GOGR | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-GRRE | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-GROR | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-GRGO | 20 (40 μL) | 200 μL |
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| ERVPRODHBA-20-AQOR | 20 (40 μL) | 200 μL |
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This region includes a endogenous retrovirus long-terminal repeat (LTR)-derived sequence that binds SRY (sex determining region Y)-box 2 (SOX2) and functions as an enhancer of the proline dehydrogenase (oxidase) 1 (PRODH) gene. This sequence acts synergistically with a CG-rich region downstream of the transcription start site to promote expression of PRODH. Cytosine methylation of the LTR element but not the CG-region can block enhancer activity. The orthologous sequence in chimpanzee does not function as an enhancer, suggesting that regulation by this region is human-specific. [provided by RefSeq, Oct 2015]
Gene Symbol : ERVPRODH
Gene Name : Human-specific endogenous retroviral insert (PRODH)
Chromosome : CHR 22: 0-0
Locus : 22q11.21
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