Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FMO4BA-20-REGO | 20 (40 μL) | 200 μL |
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| FMO4BA-20-REGR | 20 (40 μL) | 200 μL |
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| FMO4BA-20-ORGR | 20 (40 μL) | 200 μL |
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| FMO4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| FMO4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| FMO4BA-20-GROR | 20 (40 μL) | 200 μL |
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| FMO4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| FMO4BA-20-AQOR | 20 (40 μL) | 200 μL |
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Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Gene Symbol : FMO4
Gene Name : Flavin containing monooxygenase 4
Chromosome : CHR 1: 171,314,130-171,342,083
Locus : 1q24.3
Alt. Genes : RBM6
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