GAPDH Break Apart FISH Probe

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
GAPDHBA-20-REGO 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-REGR 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-GROR 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
GAPDHBA-20-AQOR 20 (40 μL) 200 μL color color Request Pricing

Gene Summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Gene Details

Gene Symbol : GAPDH

Gene Name : Glyceraldehyde-3-phosphate dehydrogenase

Chromosome : CHR 12: 653,440,4-653,837,4

Locus : 12p13.31

Alt. Genes : TRAP1

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