GRM6 Break Apart FISH Probe

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
GRM6BA-20-REGO 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-REGR 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-GROR 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
GRM6BA-20-AQOR 20 (40 μL) 200 μL color color Request Pricing

Gene Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

Gene Details

Gene Symbol : GRM6

Gene Name : Glutamate metabotropic receptor 6

Chromosome : CHR 5: 178,995,122-178,978,326

Locus : 5q35.3

Alt. Genes : RASA4

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