HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-DMBBA-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-ORGR | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-DMBBA-20-AQOR | 20 (40 μL) | 200 μL |
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HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Symbol : HLA-DMB
Gene Name : Major histocompatibility complex, class II, DM beta
Chromosome : CHR 6: 329,410,69-329,346,28
Locus : 6p21.32
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