This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-FBA-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-ORGR | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-FBA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Gene Symbol : HLA-F
Gene Name : Major histocompatibility complex, class I, F
Chromosome : CHR 6: 297,233,39-297,403,54
Locus : 6p22.1
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