In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HNMTBA-20-REGO | 20 (40 μL) | 200 μL |
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| HNMTBA-20-REGR | 20 (40 μL) | 200 μL |
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| HNMTBA-20-ORGR | 20 (40 μL) | 200 μL |
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| HNMTBA-20-GOGR | 20 (40 μL) | 200 μL |
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| HNMTBA-20-GRRE | 20 (40 μL) | 200 μL |
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| HNMTBA-20-GROR | 20 (40 μL) | 200 μL |
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| HNMTBA-20-GRGO | 20 (40 μL) | 200 μL |
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| HNMTBA-20-AQOR | 20 (40 μL) | 200 μL |
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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : HNMT
Gene Name : Histamine N-methyltransferase
Chromosome : CHR 2: 137,964,067-138,016,363
Locus : 2q22.1
Alt. Genes : RASA4
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