This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HOXD10BA-20-REGO | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-REGR | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-ORGR | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-GOGR | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-GRRE | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-GROR | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-GRGO | 20 (40 μL) | 200 μL |
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| HOXD10BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Gene Symbol : HOXD10
Gene Name : Homeobox D10
Chromosome : CHR 2: 176,116,763-176,119,941
Locus : 2q31.1
Alt. Genes : PREB
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