This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IDO1BA-20-REGO | 20 (40 μL) | 200 μL |
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| IDO1BA-20-REGR | 20 (40 μL) | 200 μL |
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| IDO1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| IDO1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| IDO1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| IDO1BA-20-GROR | 20 (40 μL) | 200 μL |
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| IDO1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| IDO1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Gene Symbol : IDO1
Gene Name : Indoleamine 2,3-dioxygenase 1
Chromosome : CHR 8: 399,138,08-399,287,89
Locus : 8p11.21
Alt. Genes : ATP6AP2
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