The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL12RB1BA-20-REGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-REGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-ORGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-GOGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-GRRE | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-GROR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-GRGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| IL12RB1BA-20-AQOR | 20 (40 μL) | 200 μL |
|
Request Pricing |
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Symbol : IL12RB1
Gene Name : Interleukin 12 receptor subunit beta 1
Chromosome : CHR 19: 180,990,26-180,589,93
Locus : 19p13.11
Alt. Genes : WASF2
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.