After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| INSBA-20-REGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-REGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-ORGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-GOGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-GRRE | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-GROR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-GRGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| INSBA-20-AQOR | 20 (40 μL) | 200 μL |
|
Request Pricing |
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Symbol : INS
Gene Name : Insulin
Chromosome : CHR 11: 216,120,8-215,977,8
Locus : 11p15.5
Alt. Genes : AKAP9
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.