This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITGA2BBA-20-REGO | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-REGR | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-ORGR | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-GROR | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGA2BBA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
Gene Symbol : ITGA2B
Gene Name : Integrin subunit alpha 2b
Chromosome : CHR 17: 443,896,00-443,721,80
Locus : 17q21.31
Alt. Genes : TRIM28
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