The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITPR2BA-20-REGO | 20 (40 μL) | 200 μL |
|
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| ITPR2BA-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| ITPR2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2BA-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2BA-20-AQOR | 20 (40 μL) | 200 μL |
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The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Symbol : ITPR2
Gene Name : Inositol 1,4,5-trisphosphate receptor type 2
Chromosome : CHR 12: 268,331,97-263,353,36
Locus : 12p11.23
Alt. Genes : LRPPRC
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