The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KCNQ2BA-20-REGO | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-REGR | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-GROR | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNQ2BA-20-AQOR | 20 (40 μL) | 200 μL |
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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : KCNQ2
Gene Name : Potassium voltage-gated channel subfamily Q member 2
Chromosome : CHR 20: 634,726,76-634,002,07
Locus : 20q13.33
Alt. Genes : LINC01587
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