ORS8 Break Apart FISH Probe

This region represents an origin of DNA replication that was first identified in African green monkey cells. Unlike the monkey origin, which replicates early, this human sequence replicates late in S phase. This sequence recognizes and binds Ku80 protein (X-ray repair complementing defective repair in Chinese hamster cells 5) during G1 phase, which recruits topoisomerase (DNA) II beta and results in transient double-strand breaks in this region. These breaks are important for recruitment of additional proteins involved in origin activity, including origin recognition complex subunit 2, chromatin licensing and DNA replication factor 1, and cell division cycle 45. [provided by RefSeq, Jan 2016]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ORS8BA-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ORS8BA-20-AQOR 20 (40 μL) 200 μL color color Request Pricing

Gene Summary

This region represents an origin of DNA replication that was first identified in African green monkey cells. Unlike the monkey origin, which replicates early, this human sequence replicates late in S phase. This sequence recognizes and binds Ku80 protein (X-ray repair complementing defective repair in Chinese hamster cells 5) during G1 phase, which recruits topoisomerase (DNA) II beta and results in transient double-strand breaks in this region. These breaks are important for recruitment of additional proteins involved in origin activity, including origin recognition complex subunit 2, chromatin licensing and DNA replication factor 1, and cell division cycle 45. [provided by RefSeq, Jan 2016]

Gene Details

Gene Symbol : ORS8

Gene Name : Origin-enriched sequence 8

Chromosome : CHR 7: 0-0

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