This genomic sequence represents the STin2 enhancer element in an intron of the solute carrier family 6 member 4 (SLC6A4) gene on chromosome 17. It also represents a polymorphic region consisting of a variable number of tandem repeats (VNTR), where each repeat unit is 16-17 bp in length. Three major alleles have been identified in human populations, STin2.9, STin2.10 and STin2.12, carrying 9, 10 and 12 copies of the repeat unit, respectively. Enhancer activity levels vary based on the allele, with each repeat unit making varying contributions to activity. This region can bind to transcription factors including CTCF and YB-1, and it may also co-operate with the 5-HTTLPR regulatory element, which is another VNTR polymorphic region located in the SLC6A4 promoter. Polymorphisms in this STin2 region may be associated with a variety of mood, behavioral and stress-related psychopathologies, possibly in a population-dependent fashion, in combination with other polymorphisms (such as the 5-HTTLPR), and/or related to epigenetic processes. [provided by RefSeq, Aug 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| STIN2-VNTRBA-20-REGO | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-REGR | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-ORGR | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-GOGR | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-GRRE | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-GROR | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-GRGO | 20 (40 μL) | 200 μL |
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| STIN2-VNTRBA-20-AQOR | 20 (40 μL) | 200 μL |
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This genomic sequence represents the STin2 enhancer element in an intron of the solute carrier family 6 member 4 (SLC6A4) gene on chromosome 17. It also represents a polymorphic region consisting of a variable number of tandem repeats (VNTR), where each repeat unit is 16-17 bp in length. Three major alleles have been identified in human populations, STin2.9, STin2.10 and STin2.12, carrying 9, 10 and 12 copies of the repeat unit, respectively. Enhancer activity levels vary based on the allele, with each repeat unit making varying contributions to activity. This region can bind to transcription factors including CTCF and YB-1, and it may also co-operate with the 5-HTTLPR regulatory element, which is another VNTR polymorphic region located in the SLC6A4 promoter. Polymorphisms in this STin2 region may be associated with a variety of mood, behavioral and stress-related psychopathologies, possibly in a population-dependent fashion, in combination with other polymorphisms (such as the 5-HTTLPR), and/or related to epigenetic processes. [provided by RefSeq, Aug 2017]
Gene Symbol : STIN2-VNTR
Gene Name : Serotonin transporter intronic VNTR enhancer
Chromosome : CHR 17: 0-0
Locus : 17q11.2
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