TBK1 Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]

TBK1 Details

Gene Symbol : TBK1

Gene Name : TANK binding kinase 1

Chromosome : CHR 12: 644,520,59-645,021,18

Locus : 12q14.2

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TMTC2 Summary

The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

TMTC2 Details

Gene Symbol : TMTC2

Gene Name : Transmembrane and tetratricopeptide repeat containing 2

Chromosome : CHR 12: 826,869,51-831,348,67

Locus : 12q21.31

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