| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TBL1XR1-RET-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-ORGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-RET-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Gene Symbol : RET
Gene Name : Ret proto-oncogene
Chromosome : CHR 10: 430,770,68-431,303,50
Locus : 10q11.21
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Symbol : TBL1XR1
Gene Name : Transducin beta like 1 X-linked receptor 1
Chromosome : CHR 3: 177,197,356-177,019,354
Locus : 3q26.32
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