TEC Summary

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

TEC Details

Gene Symbol : TEC

Gene Name : Tec protein tyrosine kinase

Chromosome : CHR 4: 482,698,63-481,357,82

Locus : 4p12-p11

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PASD1 Summary

This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010]

PASD1 Details

Gene Symbol : PASD1

Gene Name : PAS domain containing repressor 1

Chromosome : CHR X: 151,563,534-151,676,738

Locus : Xq28

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