TIA1 Summary

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

TIA1 Details

Gene Symbol : TIA1

Gene Name : TIA1 cytotoxic granule associated RNA binding protein

Chromosome : CHR 2: 702,487,92-702,094,43

Locus : 2p13.3

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ACTR2 Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACTR2 Details

Gene Symbol : ACTR2

Gene Name : ARP2 actin related protein 2 homolog

Chromosome : CHR 2: 652,276,94-652,712,52

Locus : 2p14

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