| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TIAM1-PCBP3-20-RERE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REOR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORRE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-OROR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GORE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOOR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRRE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GROR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQRE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQOR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Gene Symbol : TIAM1
Gene Name : T-cell lymphoma invasion and metastasis 1
Chromosome : CHR 21: 315,599,76-311,184,17
Locus : 21q22.11
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Gene Symbol : PCBP3
Gene Name : Poly(rC) binding protein 3
Chromosome : CHR 21: 458,499,60-459,424,53
Locus : 21q22.3
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