EIF2AK2 Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

EIF2AK2 Details

Gene Symbol : EIF2AK2

Gene Name : Eukaryotic translation initiation factor 2 alpha kinase 2

Chromosome : CHR 2: 371,570,64-370,992,09

Locus : 2p22.2

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TIMP1 Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

TIMP1 Details

Gene Symbol : TIMP1

Gene Name : TIMP metallopeptidase inhibitor 1

Chromosome : CHR X: 475,822,90-475,867,90

Locus : Xp11.3

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