ANXA1 Summary

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

ANXA1 Details

Gene Symbol : ANXA1

Gene Name : Annexin A1

Chromosome : CHR 9: 731,517,30-731,703,92

Locus : 9q21.13

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TIMP2 Summary

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

TIMP2 Details

Gene Symbol : TIMP2

Gene Name : TIMP metallopeptidase inhibitor 2

Chromosome : CHR 17: 789,253,89-788,529,76

Locus : 17q25.3

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