STOX2 Summary

This gene encodes a Storkhead-box_winged-helix domain containing protein. This protein is differentially expressed in decidual tissue and may be involved in the susceptibility to pre-eclampsia with fetal growth restriction. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

STOX2 Details

Gene Symbol : STOX2

Gene Name : Storkhead box 2

Chromosome : CHR 4: 183,796,330-184,023,529

Locus : 4q35.1

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TM2D1 Summary

The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

TM2D1 Details

Gene Symbol : TM2D1

Gene Name : TM2 domain containing 1

Chromosome : CHR 1: 617,254,22-616,810,46

Locus : 1p31.3

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