TMED10 Summary

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

TMED10 Details

Gene Symbol : TMED10

Gene Name : Transmembrane p24 trafficking protein 10

Chromosome : CHR 14: 751,766,45-751,314,67

Locus : 14q24.3

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TTLL5 Summary

This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]

TTLL5 Details

Gene Symbol : TTLL5

Gene Name : Tubulin tyrosine ligase like 5

Chromosome : CHR 14: 756,612,07-759,550,81

Locus : 14q24.3

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