TMEFF2 Summary

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEFF2 Details

Gene Symbol : TMEFF2

Gene Name : Transmembrane protein with EGF like and two follistatin like domains 2

Chromosome : CHR 2: 192,194,939-191,948,298

Locus : 2q32.3

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RLIM Summary

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

RLIM Details

Gene Symbol : RLIM

Gene Name : Ring finger protein, LIM domain interacting

Chromosome : CHR X: 746,146,25-745,829,75

Locus : Xq13.2

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