TMEM59 Summary

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEM59 Details

Gene Symbol : TMEM59

Gene Name : Transmembrane protein 59

Chromosome : CHR 1: 540,535,72-540,266,80

Locus : 1p32.3

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SUPT16H Summary

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

SUPT16H Details

Gene Symbol : SUPT16H

Gene Name : SPT16 homolog, facilitates chromatin remodeling subunit

Chromosome : CHR 14: 213,842,65-213,514,71

Locus : 14q11.2

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