IL1RN Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]

IL1RN Details

Gene Symbol : IL1RN

Gene Name : Interleukin 1 receptor antagonist

Chromosome : CHR 2: 113,099,364-113,134,015

Locus : 2q14.1

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TMEM87B Summary

This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]

TMEM87B Details

Gene Symbol : TMEM87B

Gene Name : Transmembrane protein 87B

Chromosome : CHR 2: 112,055,222-112,119,317

Locus : 2q13

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