SPINK2 Summary

This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SPINK2 Details

Gene Symbol : SPINK2

Gene Name : Serine peptidase inhibitor, Kazal type 2

Chromosome : CHR 4: 568,222,09-568,098,59

Locus : 4q12

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TMPRSS11D Summary

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

TMPRSS11D Details

Gene Symbol : TMPRSS11D

Gene Name : Transmembrane protease, serine 11D

Chromosome : CHR 4: 678,850,62-678,208,75

Locus : 4q13.2

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