TMPRSS2 Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

TMPRSS2 Details

Gene Symbol : TMPRSS2

Gene Name : Transmembrane protease, serine 2

Chromosome : CHR 21: 415,081,57-414,645,50

Locus : 21q22.3

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ARFGEF2 Summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

ARFGEF2 Details

Gene Symbol : ARFGEF2

Gene Name : ADP ribosylation factor guanine nucleotide exchange factor 2

Chromosome : CHR 20: 489,217,20-490,366,92

Locus : 20q13.13

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