| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TMPRSS2-ERG-20-RERE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-REOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-REGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-REGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-REAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-ORRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-OROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-ORGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-ORGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GORE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GOOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GOGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GOGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GRRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GRGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GRGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-AQRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-AQOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-AQGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-AQGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ERG-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Symbol : ERG
Gene Name : ERG, ETS transcription factor
Chromosome : CHR 21: 386,620,44-383,672,60
Locus : 21q22.2
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Symbol : TMPRSS2
Gene Name : Transmembrane protease, serine 2
Chromosome : CHR 21: 415,081,57-414,645,50
Locus : 21q22.3
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