| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TMPRSS2-ETV1-20-RERE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-REOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-REGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-REGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-OROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-ORGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GORE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-ETV1-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Gene Symbol : ETV1
Gene Name : ETS variant 1
Chromosome : CHR 7: 139,914,24-138,912,28
Locus : 7p21.2
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Symbol : TMPRSS2
Gene Name : Transmembrane protease, serine 2
Chromosome : CHR 21: 415,081,57-414,645,50
Locus : 21q22.3
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