TMPRSS2 Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

TMPRSS2 Details

Gene Symbol : TMPRSS2

Gene Name : Transmembrane protease, serine 2

Chromosome : CHR 21: 415,081,57-414,645,50

Locus : 21q22.3

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INPP4B Summary

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]

INPP4B Details

Gene Symbol : INPP4B

Gene Name : Inositol polyphosphate-4-phosphatase type II B

Chromosome : CHR 4: 142,846,534-142,023,159

Locus : 4q31.21

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