TMPRSS2 Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

TMPRSS2 Details

Gene Symbol : TMPRSS2

Gene Name : Transmembrane protease, serine 2

Chromosome : CHR 21: 415,081,57-414,645,50

Locus : 21q22.3

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TMEFF2 Summary

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEFF2 Details

Gene Symbol : TMEFF2

Gene Name : Transmembrane protein with EGF like and two follistatin like domains 2

Chromosome : CHR 2: 192,194,939-191,948,298

Locus : 2q32.3

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