MPST Summary

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MPST Details

Gene Symbol : MPST

Gene Name : Mercaptopyruvate sulfurtransferase

Chromosome : CHR 22: 370,196,41-370,298,21

Locus : 22q12.3

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TMPRSS6 Summary

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMPRSS6 Details

Gene Symbol : TMPRSS6

Gene Name : Transmembrane protease, serine 6

Chromosome : CHR 22: 371,097,00-370,654,35

Locus : 22q12.3

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