| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMTC2-SOCS2-20-RERE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REOR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORRE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-OROR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GORE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOOR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRRE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GROR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQRE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQOR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Symbol : SOCS2
Gene Name : Suppressor of cytokine signaling 2
Chromosome : CHR 12: 935,698,21-936,262,35
Locus : 12q22
The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Symbol : TMTC2
Gene Name : Transmembrane and tetratricopeptide repeat containing 2
Chromosome : CHR 12: 826,869,51-831,348,67
Locus : 12q21.31
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