TNIK Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

TNIK Details

Gene Symbol : TNIK

Gene Name : TRAF2 and NCK interacting kinase

Chromosome : CHR 3: 171,460,407-171,058,413

Locus : 3q26.2-q26.31

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DGCR8 Summary

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

DGCR8 Details

Gene Symbol : DGCR8

Gene Name : DGCR8, microprocessor complex subunit

Chromosome : CHR 22: 200,802,31-201,118,76

Locus : 22q11.21

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