TOM1 Summary

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

TOM1 Details

Gene Symbol : TOM1

Gene Name : Target of myb1 membrane trafficking protein

Chromosome : CHR 22: 352,992,74-353,479,93

Locus : 22q12.3

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ARFGEF2 Summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

ARFGEF2 Details

Gene Symbol : ARFGEF2

Gene Name : ADP ribosylation factor guanine nucleotide exchange factor 2

Chromosome : CHR 20: 489,217,20-490,366,92

Locus : 20q13.13

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