EPHB2 Summary

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

EPHB2 Details

Gene Symbol : EPHB2

Gene Name : EPH receptor B2

Chromosome : CHR 1: 227,107,69-229,214,99

Locus : 1p36.12

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TOMM20 Details

Gene Symbol : TOMM20

Gene Name : Translocase of outer mitochondrial membrane 20

Chromosome : CHR 1: 235,128,940-235,109,340

Locus : 1q42.3

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