TOPBP1 Summary

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

TOPBP1 Details

Gene Symbol : TOPBP1

Gene Name : DNA topoisomerase II binding protein 1

Chromosome : CHR 3: 133,662,379-133,600,604

Locus : 3q22.1

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SPDEF Summary

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SPDEF Details

Gene Symbol : SPDEF

Gene Name : SAM pointed domain containing ETS transcription factor

Chromosome : CHR 6: 345,563,32-345,378,01

Locus : 6p21.31

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