| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOX3-PHKB-20-RERE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REOR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORRE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-OROR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GORE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOOR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRRE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GROR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQRE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQOR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQAQ | 20 (40 μL) | 200 μL |
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Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]
Gene Symbol : PHKB
Gene Name : Phosphorylase kinase regulatory subunit beta
Chromosome : CHR 16: 474,611,30-477,015,22
Locus : 16q12.1
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Symbol : TOX3
Gene Name : TOX high mobility group box family member 3
Chromosome : CHR 16: 525,478,01-524,364,14
Locus : 16q12.1
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