TP53BP1 Summary

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

TP53BP1 Details

Gene Symbol : TP53BP1

Gene Name : Tumor protein p53 binding protein 1

Chromosome : CHR 15: 435,105,08-434,030,63

Locus : 15q15.3

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ATP8B4 Summary

This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

ATP8B4 Details

Gene Symbol : ATP8B4

Gene Name : ATPase phospholipid transporting 8B4 (putative)

Chromosome : CHR 15: 501,820,95-498,582,37

Locus : 15q21.2

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