TPM4 Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

TPM4 Details

Gene Symbol : TPM4

Gene Name : Tropomyosin 4

Chromosome : CHR 19: 160,675,06-161,030,04

Locus : 19p13.12-p13.11

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IGFL2 Summary

IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

IGFL2 Details

Gene Symbol : IGFL2

Gene Name : IGF like family member 2

Chromosome : CHR 19: 460,785,12-461,950,96

Locus : 19q13.32

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