TRIO Summary

This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

TRIO Details

Gene Symbol : TRIO

Gene Name : Trio Rho guanine nucleotide exchange factor

Chromosome : CHR 5: 141,433,49-145,102,03

Locus : 5p15.2

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ADAMTS12 Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

ADAMTS12 Details

Gene Symbol : ADAMTS12

Gene Name : ADAM metallopeptidase with thrombospondin type 1 motif 12

Chromosome : CHR 5: 338,921,79-335,235,34

Locus : 5p13.3-p13.2

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