GTSE1 Summary

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

GTSE1 Details

Gene Symbol : GTSE1

Gene Name : G2 and S-phase expressed 1

Chromosome : CHR 22: 462,958,78-463,336,98

Locus : 22q13.31

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TRMU Summary

This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TRMU Details

Gene Symbol : TRMU

Gene Name : TRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

Chromosome : CHR 22: 463,354,00-463,573,39

Locus : 22q13.31

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