| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRRAP-PRKAR2B-20-RERE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REOR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORRE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-OROR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GORE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOOR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRRE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GROR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQRE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQOR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQAQ | 20 (40 μL) | 200 μL |
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cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Gene Symbol : PRKAR2B
Gene Name : Protein kinase cAMP-dependent type II regulatory subunit beta
Chromosome : CHR 7: 107,044,727-107,161,810
Locus : 7q22.3
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Symbol : TRRAP
Gene Name : Transformation/transcription domain associated protein
Chromosome : CHR 7: 988,784,89-990,132,42
Locus : 7q22.1
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