PKD2 Summary

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]

PKD2 Details

Gene Symbol : PKD2

Gene Name : Polycystin 2, transient receptor potential cation channel

Chromosome : CHR 4: 880,076,46-880,777,78

Locus : 4q22.1

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TSPAN5 Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN5 Details

Gene Symbol : TSPAN5

Gene Name : Tetraspanin 5

Chromosome : CHR 4: 986,586,60-984,703,66

Locus : 4q23

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